It is crucial to right-click the main executable and select "Run as Administrator." This allows the portable environment to temporarily register the components it needs to run.
: A modern, free IDE from Microsoft that supports VB.NET, which is the official successor to VB6. Legacy Project Support For those maintaining old codebases: Thread: NanoVB6 aka Portable VB6 - VBForums It is crucial to right-click the main executable